The amplification of ribosomal RNA genes involves a rolling circle intermediate.

نویسندگان

  • D Hourcade
  • D Dressler
  • J Wolfson
چکیده

During the development of Xenopus oocytes there is a special DNA synthesis that leads to a thousandfold amplification of the genes that code for ribosomal RNA. We have used the electron microscope to study this process. Our primary observation is the presence of ribosomal DNA in rolling-circle intermediates at the time of amplification. We believe that these intermediates are involved in the amplification process, and as such offer the first example of the involvement of a rolling circle in the replication of eukaryotic DNA.

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عنوان ژورنال:
  • Proceedings of the National Academy of Sciences of the United States of America

دوره 70 10  شماره 

صفحات  -

تاریخ انتشار 1973